Figure 2.

Plasma hormone levels at the time of the PET and fMRI scans and n-back performance scores during scanning during three conditions: hormone suppression (Lupron alone), estradiol add-back, and progesterone add-back (mean ± s.e.m.). Also see Table 2. (a, b) As expected, during hypogonadism (Lupron alone), plasma levels of estradiol and progesterone were suppressed ( < 20 pg ml⁻¹ and < 0.6 ng ml⁻¹, respectively), whereas during estradiol replacement, plasma levels of estradiol were in the mid-follicular phase range, and during progesterone replacement plasma levels of progesterone were comparable to those in the mid-luteal phase. Hormone levels did not differ significantly between genotypes during any of the three hormone conditions in PET or fMRI. (c, d) No significant main or interactive effects of hormone and genotype were observed in either the 0-back or the 2-back performance scores. fMRI, functional magnetic resonance imaging; PET, positron emission tomography.