Table 3.
Predictors of local progression free survival after radioembolization. Variables with p<0.1 in the univariate model were included in the multivariate model. RR = relative risk of progression. All patients in this study received standard 120 Gy (glass) or BSA (resin) dosing, and patients who received a higher dose (radiation segmentectomy or lobectomy) were excluded. The lack of variation in dosing, combined with the wide variation in number of particles delivered, could explain the lack of correlation between mean dose and outcomes in this study.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| RR | p | RR | p | |
| Age | 1.0 | 0.78 | ||
| Primary site | ||||
| Breast | 0.88 | 0.60 | ||
| Colorectal | 1.3 | 0.17 | ||
| Other or unknown | 1 | |||
| Child Pugh score | 1.2 | 0.33 | ||
| CEA | 1.0003 | < 0.001 * | 1.0003 | < 0.001 * |
| Extrahepatic disease | 1.6 | 0.025 * | 1.5 | 0.058 |
| Percent liver replaced with tumor | 1.9 | 0.15 | ||
| Lung shunt fraction | 21 | 0.23 | ||
| T:N ratio on MAA scan | 1.0 | 0.88 | ||
| Tumor dose (mean) | 1.0 | 0.42 | ||
| Tumor dose (1st percentile) | 0.997 | 0.025 * | 0.997 | 0.028 * |
| Liver dose (mean) | 1.0 | 0.57 | ||
| Liver dose (1st percentile) | 1.0 | 0.58 | ||