FIGURE 3: aMMR is required for diet induced homeostatic rewiring in vivo.

A. Immunostaining of TOMM20 and DRP1 on sorted microglia from mice Drp1^MGWT or Drp1^MGKO

B. Western Blot against DRP1 on sorted microglia from mice Drp1^MGWT or Drp1^MGKO

C. Graphs showing the overnight fasted glycemia, the 2hours fasted glycemia and the insulin released from Drp1^MGWT or Drp1^MGKO fed with control diet (n=5 to 11).

D. Graphs showing the overnight fasted glycemia, the 2hours fasted glycemia and the insulin released from Drp1^MGWT or Drp1^MGKO fed with 3 day high fat diet (n=5 to 11).

Data are presented as mean ±SEM. *p<0.05, **p<0.01, ***p<0.001 as determined by two-tailed Student’s test and two-way ANOVA followed by Bonferroni post hoc test.