Figure 4 |. In vitro EC EndMT models reorganize active epigenetic landscapes with subtype specificity.

(A), Upset plot of induced peaks for siERG (grey), IL1B (pink), and TGFB2 (blue) across EC1–4. Intersection size represents the number of genes at each intersection. (B), Heatmap of top motifs enriched in IL1B-affected peaks. (C), Heatmap of top motifs enriched in siERG-affected peaks. (D), Heatmap of top motifs enriched in TGFB2-affected peaks. For B-D, top TFs for each EC subtype are selected based on ascending p-value. Rows (TFs) and columns (EC subtypes) are clustered based on enrichment score (ES).