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[Preprint]. 2023 Aug 10:2023.04.03.535495. Originally published 2023 Apr 6. [Version 2] doi: 10.1101/2023.04.03.535495

Figure 4 |. EC activating perturbations in vitro elicit EC subtype-specific transcriptional responses.

Figure 4 |

(A), Upset plots of up- and down-regulated DEGs across EC subtypes with siERG (grey), IL1B (pink), and TGFB2 (blue). Intersection size represents the number of genes at each intersection. (B), PEA for EC3–4 up- and down-regulated DEGs with TGFB2 compared to control media. (C), PEA for EC2–4 up- and down-regulated DEGs with IL1B compared to control media. (D), PEA for EC1–4 up- and down-regulated DEGs with siERG compared to siSCR. (E), PEA comparing up- and down-regulated DEGs that are mutually exclusive and shared between IL1B and siERG in EC3.