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[Preprint]. 2023 Jun 22:2023.04.06.535891. Originally published 2023 Apr 6. [Version 2] doi: 10.1101/2023.04.06.535891

Figure 6: ISN regulation of sugar and water ingestion model.

Figure 6:

Hunger signals activate the ISN while thirst signals inhibit the ISNs. ISNs use dILP3 as a neurotransmitter and require amontillado (amon) for neuropeptide processing. ISN activity inhibits BiT, which in turn inhibits CCHa2R-RA neurons. CCAP neurons are downstream of the ISNs, connected via Cowboy, VESAa1, BiT2 and CCHa2R-RA neurons. BiT activity inhibits sugar ingestion and promotes water ingestion. CCAP activity promotes sugar ingestion and inhibits water ingestion. CCHa2R-RA activity inhibits water ingestion.