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. Author manuscript; available in PMC: 2023 Apr 14.
Published in final edited form as: Curr Opin Microbiol. 2020 Jul 11;56:59–66. doi: 10.1016/j.mib.2020.06.008

Figure 3. Secretor status.

Figure 3.

• ~80% of humans are secretors, meaning their H antigens are released from the originating cell. FUT2, the causal locus for secretion, encodes a fucosyltransferase that produces soluble H antigen which is decorated by ABO oligosaccharides.

• Secretor status is autosomal dominant and non-secretors are homozygous for nonsense mutations at the FUT2 locus.

• These soluble antigens can be found in bodily fluids beyond the circulatory system such as saliva, tears, urine, and mucus.