Table 1:

Statistical validation of MR results. The table shows the results of heterogeneity and pleiotropy tests performed for all biomarkers that had significant association with subcortical volume. Table 1A shows the results for proteins and 1B shows the results for the metabolites. Q refers to Cochran’s Q estimate for the heterogeneity test; DF is the degree of freedom. The Int refers to the MR-Egger intercept for the pleiotropy test and SE is the standard error of the Intercept.

Biomarker ID (Exposure)	Region (Outcome)	Heterogeneity Test			Pleiotropy test
		Q	Q_DF	p-val	Int	SE	p-val
(1A) Proteins
SCGB1C1.5960.49.3	Accumbens	7.12	16	0.971	−0.12	0.88	0.893
SERPING1.4479.14.2	Accumbens	43.59	35	0.151	0.12	0.63	0.852
GZMA.3440.7.2	Amygdala	21.54	26	0.714	−0.45	2.26	0.841
TMPRSS11D.6547.83.3	Caudate	58.99	46	0.095	2.85	2.78	0.311
TXNDC12.4815.25.3	Caudate	87.65	80	0.261	−2.37	1.63	0.15
C5orf38.6378.2.3	Hippocampus	41.42	43	0.540	0.11	1.82	0.952
CPNE1.5346.24.3	Hippocampus	28.60	24	0.236	1.62	2.46	0.516
CTF1.13732.79.3	Hippocampus	34.77	28	0.177	−1.97	2.60	0.454
VIMP.11286.78.3	Hippocampus	24.13	28	0.675	−0.30	2.17	0.891
ASIP.5676.54.3	Putamen	55.63	49	0.239	3.79	1.97	0.061
CTRB1.5671.1.3	Thalamus	21.99	40	0.991	1.57	2.47	0.528
(1B) Metabolites
Uridine	Amygdala	11.90	21	0.942	1.1	2.26	0.634
Arachidonate	Amygdala	20.25	28	0.855	0.41	1.01	0.686
Mannose	Caudate	32.76	30	0.333	4.71	2.81	0.104
Urate	Thalamus	23.63	27	0.650	−1.64	3.29	0.623
1-arachidonoylglycerphosphocholine	Thalamus	25.42	22	0.277	−0.28	2.64	0.915
N-acetylornithine	Thalamus	18.74	25	0.809	3.78	2.27	0.109