Table 1.
Details of cancer genome-wide association studies used in the Mendelian randomisation analysis.
| Cancer | Cases | Controls | PubMed ID | Number of contributing studies |
GWAS Catalogue ID | |||
|---|---|---|---|---|---|---|---|---|
| Breast | 133,384 | Triple negative | 2,006 | 20,815 (subtype analysis) | 113,789 | 32424353 | 82 | GCST010098 GCST010099 GCST010100 |
| Luminal A | 7,325 | |||||||
| Luminal B | 1,682 | |||||||
| HER2 enriched | 718 | |||||||
| HER2 negative luminal B | 1,779 | |||||||
| Colorectal | 73,673 | 86,854 | 36539618 | 16 | GCST90129505 | |||
| Endometrial | 8,758 | 46,126 | 30093612 | 17 | GCST006465 | |||
| Lung | 29,266 | Ever-smoked | 23,223 | 16,964 | 56,450 | 28604730 | 26 | GCST004744 GCST004746 GCST004747 GCST004748 GCST004749 GCST004750 |
| Never-smoked | 2,355 | 7,504 | ||||||
| Adenocarcinoma | 11,273 | 55,483 | ||||||
| Squamous cell carcinoma | 7,426 | 55,627 | ||||||
| Small cell lung cancer | 2,664 | 21,444 | ||||||
| Oesophageal | 16,790 | 32,476 | 35882562 | 5 | NA | |||
| Ovarian | 26,293 | Invasive high grade serous | 13,037 | 40,941 (subtype analysis) | 68,502 | 28346442 | 77 | GCST004415 GCST004416 GCST004417 GCST004418 GCST004419 GCST004461 GCST004462 GCST004478 GCST004479 GCST004480 GCST004481 |
| All serous | 16,003 | |||||||
| Invasive mucinous | 1,417 | |||||||
| All mucinous | 2,566 | |||||||
| All low malignant potential | 3,103 | |||||||
| Invasive low grade serous and low malignant potential serous | 2,966 | |||||||
| Invasive low grade serous cases | 1,012 | |||||||
| Endometrioid | 2,810 | |||||||
| Clear cell | 1,366 | |||||||
| Low malignant potential serous | 1,954 | |||||||
| Low malignant potential mucinous | 1,149 | |||||||
| Prostate | 79,194 | 61,112 | 29892016 | 8 | GCST006085 | |||
| Renal | 10,784 | 20,406 | 28598434 | 5 | GCST004710 | |||