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. 2023 Apr 14;18(4):e0284248. doi: 10.1371/journal.pone.0284248

Table 3. Treatments and support.

Global AKI No AKI p
(n = 1642) (n = 618, 40.1%) (n = 923, 59.9%)
COVID-19 treatment
Hydroxychloroquine/ Chloroquine. n (%) 1443 (90.8) 553(89.8) 840 (91.2) 0.345
Lopinavir/Ritonavir. n (%) 949 (60.8) 358 (60.1) 552 (60.4) 0.899
Remdesivir. n (%) 29 (2.0) 11 (2.0) 18 (2.1) 0.925
Interferon b. n (%) 352 (23.5) 169 (29.5) 168 (19.1) <0.001
Tocilizumab. n (%) 527 (35.4) 182 (32.6) 327 (37.2) 0.073
Corticosteroids 756 (49.2) 310 (52.6) 425 (47.4) 0.048
for shock n (%) 53 (3.2) 44 (7.1) 9 (1.0) <0.001
for ARDS n (%) 645 (39.3) 248 (40.1) 378 (41.0) 0.747
for asthma/bronchial hyperreactivity n (%) 67 (4.1 27 (4.4) 39 (4.2) 0.891
Hemodynamic support
Noradrenaline n (%) 1112 (67.7) 518 (83.8) 560 (60.7) <0.001
Dobutamine n (%) 27 (1.6) 20 (3.2) 6 (0.7) <0.001
Dopamine n (%) 7 (0.4) 4 (0.6) 3 (0.3) 0.448
Adrenaline n (%) 11 (0.7) 8 (1.3) 3 (0.3) 0.033
Levosimendan n (%) 2 (0.1) 1 (0.2) 1 (0.1) 1.000
Respiratory Support
Oxygen n (%) 924 (56.33) 349 (56.5) 547 (59.3) 0.276
High-flow nasal cannula n (%) 651 (39.6) 214 (34.6) 412 (59.3) <0.001
Non-invasive ventilation n (%) 307 (18.7) 125 (20.2) 172 (18.6) 0.438
Mechanical ventilation n (%) 1326 (80.8) 568 (91.9) 717 (77.7) <0.001
Prone position n (%) 1058 (64.4) 462 (74.8) 563 (61) <0.001
ECCO2R n (%) 7 (0.4) 5 (0.8) 2 (0.2) 0.124
ECMO n (%) 42 (2.9) 19 (3.1) 23 (2.5) 0.491

ARDS- Acute respiratory distress syndrome

ICU- Intensive care unit

ECCO2R- extracorporeal membrane carbon dioxide removal

ECMO- Extracorporeal membrane oxygenation

AKI- Acute kidney injury.