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. 2023 Apr 14;9(15):eadf4568. doi: 10.1126/sciadv.adf4568

Fig. 1. Preparation of MB@CPs and optimization of CP monomers.

Fig. 1.

Schematic illustrations of the synthesis of (A) CP monomers and (B) corresponding MB@CPs. The zwitterionic CPs were installed on the MB surfaces via precipitation polymerization. (C) SDS–polyacrylamide gel electrophoresis (SDS-PAGE) analysis of the proteins isolated from the MB@CPs bearing different headgroups. All the MB@CPs (1 mg/ml) were incubated with 10% fetal bovine serum (FBS) before magnetic isolation of the proteins. (D) Mechanism for the adhesion of EVs on a MB@CP via the high-affinity CP-PC interaction, which forms two quaternary nitrogen-phosphorus pairs to constitute a quadrupole. (E) Isolation efficiencies of the MB@CPs bearing different headgroups such as Et (ethyl), iPr (isopropyl), and MOE (methoxyethyl). (F) Scanning electron microscopy image of SW620 EVs adhered on the surfaces of MB@CP-iPr. Scale bar, 200 nm.