Fig. 4. Immature intracellular structure of Lmna^Q353R/WT iPSCMs.

(A) Electron microscopic images showing morphological properties of isogenic control (Con) and LMNA^Q353R/WT (Q353R) of iPS cell–derived CMs (iPSCMs). (B) Sarcomere density of iPSCMs counted per 625 μm². n = 100 (WT, Q353R; data were obtained from five differentiation batches). *P < 0.05. (C) Representative image of the long and short axis of an iPSCM nucleus (left). Aspect ratio of iPSCM nuclei is also shown (right). n = 72 (WT) and 82 (Q353R); data were obtained from five differentiation batches. *P < 0.05.