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. 2023 Apr 3;120(15):e2208737120. doi: 10.1073/pnas.2208737120

Fig. 7.

Fig. 7.

Mass spectrometry. Native mass spectrometry suggests additional modes of action for SVD 6d. (A) mass spectra of vancomycin with MurJ (Bottom), lipid II with MurJ (Middle), and vancomycin with MurJ:lipid II complex (Top). Ternary complex of MurJ:lipid II:vancomycin is observed (top spectra). (B) mass spectra of SVD 6d with MurJ (Bottom), lipid II with MurJ (Middle), and SVD 6d with MurJ:lipid II complex (Top). No ternary complex and complete loss of lipid II binding from MurJ (top spectra). Charge state 6+ is shown in both cases.