Table 1. Coutinho stages of ATTRv-PN and modified Peripheral neuropathy disability score (mPND).

Coutinho stages	mPND
I. Sensory and motor neuropathy limited to the lower limbs. Mild motor impairment. Ambulation without any gait aids.	I. Sensory disturbances but preserved walking capacity (no motor impairment)
	II. Difficulty walking but no need for a gait aid
II. Gait aid required. Neuropathy progress to upper limbs and trunk. Amyotrophy in upper and lower limbs. Moderate motor impairment.	IIIa. One stick or one crutch required for walking
	IIIb. Two sticks, two crutches or a walker required for walking
III. Terminal stage, bedridden or wheelchair bound. Severe sensory, motor and autonomic neuropathy in all limbs.	IV. Patient confined to a wheelchair or bed