Table 2. Differential diagnosis of hereditary transthyretin amyloidosis with peripheral neuropathy.

Differential diagnosis	Clues for the differential diagnosis
Diabetic neuropathy	Poor glycemic control and mild motor involvement
CIDP	Proximal and distal weakness and non-uniform demyelination on NCS
Leprosy	Multiple mononeuropathies/asymmetric neuropathy, typical skin lesions
Toxic neuropathies	Bortezomib, thalidomide, vincristine, alcohol abuse
Fabry	Angiokeratomas, stroke, and alpha-glucosidase deficiency
Charcot-Marie-Tooth	Mild sensation loss and no autonomic involvement
HSAN	No or mild motor involvement
Immunoglobulin light-chain amyloidosis	Monoclonal gammopathy in the serum and/or urine, abnormal kappa/lambda ratio, mass-spectrometry, bone marrow biopsy

Abbreviations: CIDP, chronic inflammatory polyradiculopathy; HSAN, hereditary motor and autonomic neuropathy; NCS, nerve conduction studies.