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. 2023 Apr 14;13:6118. doi: 10.1038/s41598-023-32854-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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X-ray crystallographic structures of human TTBK1 in complex with several analogs and corresponding thermal shift data for TTBK1/2. (A) AMG28 (PDB code: 7ZHN) is shown in brown, 10 (PDB code: 7ZHQ) in yellow, and 9 (PDB code: 7ZHP) in pink stick representation, respectively. Image created using Schrödinger PyMOL 2.5. (B) 3 (PDB code: 7ZHO) is shown in pink. The hinge region and αC helix are labeled in each panel and hydrogen bonds are included as black dashed lines. Image created using Schrödinger PyMOL 2.5. (C) Table of thermal shift (ΔTm) data for TTBK inhibitors.