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. 2023 Apr 14;14(4):271. doi: 10.1038/s41419-023-05803-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Briefly, CYP1B1 metabolizes AA to 20-HETE to activate the PKC pathway, thereby increasing FBXO10 expression, which promotes ACSL4 degradation and leads to tumor cell resistance to ferroptosis. The lower right side shows the chemical structures of AA and 20-HETE.