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. 2023 Apr 14;13:6126. doi: 10.1038/s41598-023-33151-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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EPC alleviated CSE-induced ferroptosis in BECs by transporting Exo. (A) The concentration of Exo in the cell supernatant was evaluated by ELISA. *P < 0.05 vs. EPC + DMSO. (B) MDA and SOD levels in the cell supernatant were determined by ELISA. (C) The relative content of catalytic Fe (II) in BECs was detected by FCM. (D) Western blot detection of ferroptosis markers TfR, FtL, and GPX4 expressions in BECs. *P < 0.05 vs. Control, #P < 0.05 vs. CSE, &P < 0.05 vs. EPC + DMSO. The data were presented in the form of mean ± standard deviation. n = 3.