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. 2023 Apr 14;13:6126. doi: 10.1038/s41598-023-33151-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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miR-26a-5p targeting PTGS2 affected CSE-induced ferroptosis in BECs. (A) Targeting sequences of miR-26a-5p and PTGS2. (B) Dual-luciferase verification of miR-26a-5p and PTGS2 relationship. (C) miR-26a-5p and PTGS2 mRNA expression, and PTGS2 protein expression. (D) ELISA detection of PGE2, lipid peroxidation MDA and SOD. (E) The content of catalytic Fe (II) was evaluated by FCM. (F) The protein expression of ferroptosis markers TfR, FtL, and GPX4. *P < 0.05 vs. NC, #P < 0.05 vs. miR-26a-5p mimics, &P < 0.05 vs. miR-26a-5p mimics + vector. The data were presented in the form of mean ± standard deviation. n = 3.