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. 2022 Nov 2;44(5):1014–1028. doi: 10.1038/s41401-022-01010-5

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 5 — a Representative immunoblot analysis of Caspase-6 and Caspase-8 levels in liver tissues from four groups of mice. GAPDH as loading control. b Immunohistochemistry staining showing the effects of LPT1 treatment on cleaved Caspase-6 (p18 subunit) in MAFLD mice liver tissues. Scale bars, 100 μm. n = 18 biologically independent experiments. c Immunohistochemistry staining showing the effects of LPT1 treatment on cleaved Caspase-8 (p18 subunit) in MAFLD mice liver tissues. Scale bars, 100 μm. n = 18 biologically independent experiments. The data were presented as Means ± SEM and analyzed by One way-ANOVA followed by Tukey’s post hoc test. **P < 0.01 vs Chow; ^#P < 0.05 vs HFHF. NS no significance.