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. 2022 Nov 8;44(5):1051–1065. doi: 10.1038/s41401-022-00997-1

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — a Chemical structure formula of ALM. b Diagrammatic representation of the main modes of action of ALM. The blood glucose (c), 24 h total urine microalbumin content (d), serum triglyceride content (e) and serum cholesterol content (f) in each group. g H&E, PAS, Sirius red staining and Immunofluorescence staining of CD3 (magnification, ×200), renal tubular injury index (h), mesanglal expansion index (i) and Collagen volume fraction (j). db/m db/m mice, db/db db/db mice, ALM ALM treated db/db mice. ^*P < 0.05 vs. db/m group. ^#P < 0.05 vs. db/db group. Animal experiments: n = 6.