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. 2022 Nov 8;44(5):1051–1065. doi: 10.1038/s41401-022-00997-1

Fig. 8. ALM resisted high glucose-mediated phenotypic loss of renal tubular epithelial cells through upregulation of RXRα and CDX2.

Fig. 8

NRK-52E cells were given NG or HG culture, HG + DMSO, HG + ALM respectively, and transfected with RXRα si RNA after ALM intervention. Immunoblot bands (a, b) and quantitative data (c–j) of RXRα, CDX2 and CFTR, Active-β-catenin, Snail, E-cadherin, Col-III, and Vimentin in each group of cells. NRK-52E cells were given NG or HG culture, HG + DMSO, HG + ALM, respectively, and transfected with CDX2 sh RNA plasmid after ALM intervention. Immunoblot bands (k, l) and quantitative data (m–s) of CDX2 and CFTR, Active-β-catenin, Snail, E-cadherin, Col-III, and Vimentin in each group of cells. *P < 0.05 vs. NG group. #P < 0.05 vs. HG + DMSO group. &P < 0.05 vs. ALM + Ctrl si. △P < 0.05 vs. ALM + Vector group. All Data are mean ± SD from three independently performed experiments.