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. 2023 Apr 17;133(8):e162519. doi: 10.1172/JCI162519

Figure 5. Changes in SenMayo genes and regulators of bone remodeling in response to local osteocyte-specific versus systemic SnC clearance.

Figure 5

(A and B) After 2 weeks, a comparison of the 2 AP-treated groups (INK versus DMP) revealed broader downregulation of SASP- and Sn-related genes in the systemic SnC clearance model (INK) versus the local osteocyte-specific model (DMP). (C) BioPlanet 2019 pathway analysis emphasized the senescence and autophagy as well as the p53/Il2/Egf pathways as being regulated in the INK model, whereas the Wnt/Lrp6/IL10/IL4 pathways were regulated in the DMP model. (D and E) Changes in mRNA expression of (D) Sost (encoding sclerostin) and (E) Rankl (also known as Tnfsf11) in response to systemic (INK) versus local osteocyte-specific (DMP) senolysis (INK Veh n = 15, INK AP n = 15; DMP Veh n = 15, DMP AP n = 15). NS, P > 0.05; **P < 0.01, by independent samples Student’s t test or Wilcoxon rank-sum test, as appropriate.