Table 1.
Participants’ characteristics at baseline according to decline in kidney function
| Total (n = 10,547) |
Normal eGFR decliner (n = 10,214) |
Rapid eGFR decliner (n = 333) |
||
|---|---|---|---|---|
| Age (years) | 53.3 ± 11.6 | 53.3 ± 11.6 | 52.0 ± 13.4 | |
| Sex (male) | 5320 (50.4) | 5134 (50.3) | 186 (55.9) | |
| BMI (kg/m2) | 22.9 ± 2.99 | 22.9 ± 3.0 | 23.1 ± 3.2 | |
| Systolic blood pressure* (mmHg) | 123.8 ± 17.8 | 123.7 ± 17.8 | 125.8 ± 18.5 | |
| Diastolic blood pressure* (mmHg) | 74.8 ± 11.0 | 74.7 ± 11.0 | 77.0 ± 11.3 | |
| 140/90 mmHg or higher* | 1217 (11.5) | 1157 (11.3) | 60 (18.0) | |
| Hemoglobin (g/dL) | 13.9 ± 1.40 | 13.9 ± 1.39 | 13.8 ± 1.64 | |
| Albumin* (g/dL) | 4.51 ± 0.23 | 4.52 ± 0.23 | 4.45 ± 0.23 | |
| Alanine transferase (IU/L) | 18 (14–25) | 18 (14–25) | 18 (13–25) | |
| Creatinine (mg/dL) | 0.71 ± 0.16 | 0.71 ± 0.16 | 0.72 ± 0.17 | |
| Estimated GFR* (mL/min/1.73 m2) | 83.1 ± 10.1 | 83.1 ± 9.97 | 84.3 ± 12.8 | |
| Uric acid (mg/dL) | 5.22 ± 1.23 | 5.22 ± 1.23 | 5.22 ± 1.31 | |
| Total cholesterol (mg/dL) | 203.1 ± 34.8 | 203.1 ± 34.7 | 201.4 ± 036.7 | |
| HDL cholesterol* (mg/dL) | 58.9 ± 15.1 | 59.0 ± 15.2 | 55.9 ± 14.3 | |
| Lower than 40 mg/dL | 812 (7.7) | 786 (7.7) | 26 (7.8) | |
| Non-HDL cholesterol (mg/dL) | 144.2 ± 35.1 | 144.2 ± 35.0 | 145.5 ± 36.3 | |
| 170 mg/dL or higher | 2390 (22.7) | 2309 (22.6) | 81 (24.3) | |
| Triglyceride (mg/dL) | 96 (69–137) | 96 (69–137) | 96 (71–142) | |
| 150 mg/dL or higher | 2126 (20.2) | 2054 (20.1) | 72 (21.6) | |
| C-reactive protein (mg/dL) | 0.1 (0–0.1) | 0.1 (0–0.1) | 0.1 (0–0.1) | |
| Fasting plasma glucose (mg/dL) | 97 ± 16 | 97 ± 16 | 99 ± 22 | |
| HbA1c, NGSP (%) | 5.4 ± 0.7 | 5.4 ± 0.7 | 5.4 ± 1.0 | |
| Potential diabetes mellitus from baseline data | 501 (4.8) | 478 (4.7) | 23 (6.9) | |
| Dyslipidemia on treatment | 59 (0.56) | 57 (0.6) | 2 (0.6) | |
| Hypertension on treatment* | 325 (3.1) | 301 (2.9) | 24 (7.2) | |
| History of stroke | 20 (0.19) | 19 (0.2) | 1 (0.3) | |
| History of ischemic heart disease* | 43 (0.41) | 39 (0.4) | 4 (1.2) | |
According to the property of each datum, the data are expressed as mean and standard deviation, median and quartile range, or subject number and percentage
*P < 0.05 between normal decliner and rapid decliner