Table 3.

Univariable and multivariable analyses of the association between clinicopathological variables and miRNA signature status with DFS and OS of patients.

Clinicopathological feature	DFS						OS
	Univariable analysis			Multivariable analysis			Univariable analysis			Multivariable analysis
	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
Age
>60	1.099	0.590–2.049	0.766				1.179	0.612–2.272	0.623
≤60	1	Reference					1	Reference
Gender
Male	1.370	0.735–2.555	0.322				0.826	0.441–1.549	0.552
Female	1	Reference					1	Reference
Tumor stage
Late (III & IV)	4.412	2.257–8.624	<0.001	4.101	2.091–8.045	<0.001	2.952	1.515–5.752	0.001	2.773	1.415–5.433	0.003
Early (0, I & II)	1	Reference		1	Reference		1	Reference		1	Reference
Tumor location
Left & Rectum	1.598	0.763–3.349	0.214				0.621	0.316–1.222	0.168
Right	1	Reference					1	Reference
Tumor size
≥4 cm	1.517	0.826–2.785	0.179				1.617	0.858–3.048	0.137
<4 cm	1	Reference					1	Reference
miRNA signature
high	2.269	1.194–4.313	0.012	1.949	1.021–3.718	0.043	1.833	0.952–3.531	0.070	1.599	0.825–3.097	0.164
low	1	Reference		1	Reference		1	Reference		1	Reference