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. 2023 Jan 18;8(4):871–883. doi: 10.1016/j.ekir.2023.01.013

Figure 3.

Figure 3

Urinary T cells predict clinical response and early relapses. (a, b) Active renal AAV patients with higher urinary Treg and TH17 T cells show faster full response (i.e., renal BVAS of 0). (c) Patients in remission who develop a renal flare within 6 months of measurement show no difference in urinary T cell counts or monocyte chemoattractant protein-1, soluble CD163. (d) A combined predictor of elevated TH17 and absent Treg predicts renal relapse. Dashed line indicates suggest cut off value of 10 TH17 cells per 100 ml urine. Curve of Relapse free survival based on combined predictor TH17 > 10/100 ml urine and Treg = 0/100 ml urine. Cell counts and concentrations plotted +1 to visualize zeros on logarithmic scale. Statistics: logrank test, 95% confidence interval indicated by colored area, Mann-Whitney-Wilcoxon test, ns: P > 0.05. Treg, regulatory T cell; TH17, T helper 17; TH1, T helper 1.