Table 2.
Summary of urinary T cell count
| Urinary T cell count [1/100 ml urine] median (IQR) | |||||||
|---|---|---|---|---|---|---|---|
| Inception cohort | |||||||
| rAAV | nrAAV | P-value | Rem | P-value | HC | P-value | |
| CD3+ | 17599 (5459, 72194) | 597 (383, 1436) | 0.0031 | 1116 (638–2376) | < 0.0001 | 1263 (406, 2064) | 0.0005 |
| CD4+ | 1917 (667, 9626) | 6 (1, 28) | 0.0014 | 236 (45, 400) | 0.0007 | 15 (5, 75) | 0.0001 |
| CD8+ | 3766 (1131, 14658) | 8 (3, 66) | 0.0061 | 829 (381, 1277) | 1.0000 | 44 (13, 55) | 0.0031 |
| Treg | 378 (60, 698) | 0 (0, 0) | 0.0026 | 0 (0, 21) | <0.0001 | 0 (0, 1) | 0.0001 |
| TH17 | 82 (22, 281) | 0 (0, 5) | 0.0320 | 26 (0, 92) | 0.2015 | 0 (0, 1) | 0.0012 |
| TH1 | 5 (0, 75) | 0 (0, 0) | 0.1637 | 0 (0, 17) | 0.2510 | 0 (0, 0) | 0.0189 |
| Validation cohort | |||||||
| CD3+ | 10519 (5137, 20206) | 2324 (1733, 3675) | 0.4463 | 311 (140, 554) | <0.0001 | - | - |
| CD4+ | 1233 (445, 2303) | 9 (4, 777) | 0.1369 | 15 (4, 35) | 0.0007 | - | - |
| CD8+ | 1215 (306, 3440) | 28 (27, 334) | 0.3797 | 7 (20, 14) | <0.0001 | - | - |
| Treg | 259 (33, 535) | 9 (4, 205) | 0.9543 | 0 (0, 4) | 0.0065 | - | - |
| TH17 | 97 (41, 403) | 0 (0, 224) | 0.2861 | 4 (0, 6) | 0.0009 | - | - |
| TH1 | 0 (0, 0) | 0 (0, 0) | 1.0000 | 0 (0, 0) | 0.9327 | - | - |
AAV, ANCA-associated vasculitis; ANCA, antineutrophil cytoplasmic antibodies; HC, healthy control; IQR, interquartile range; nrAAV, nonrenal active AAV; rAAV, active renal AAV; Rem, remission.
Statistics: Kruskal-Wallis and post hoc Dunn’s test with Bonferroni correction for multiple comparisons.