Fig. 1.

Identification of mousec-Ddx, a novel circRNA most significantly up-regulated by exercise hypertrophic preconditioning. (A), Distinct circRNAs identified through unique backsplice reads; (B), Distribution of exon lengths of circRNAs; (C), Venn diagram of circRNA genomic loci of origin; (D), Heatmap analysis of sequencing data for differentially expressed circRNAs with |log2 [fold change]| >1 and P < 0.05; (E), Volcano plot of differentially expressed circRNAs; (F), Similarity of DdX60 sequences from exon 19–21 among human, mouse and rat, calculated based on pairwise alignment; (G), Verification of the full sequence of c-Ddx by Sanger sequence analysis. Abbreviations: circRNA, circular RNA; c-Ddx, circ-Ddx60;