Yu 1999.
Methods | Randomised controlled trial, parallel groups. Study period: August 1995 to December 1998 |
|
Participants | Setting: hospital outpatients Treatment group (males): 30 (18) Control group: 30 (not available) Age Treatment group: 6 to 43 years; Control group: not available Inclusion: Epilepsy Exclusion: space occupying lesions on CT scan Seizure type: not available Duration of epilepsy Treatment group: 3 months to 10 years; Control group: not available Aetiology of epilepsy: not available Baseline seizure frequency: not available Number of AEDs taken: not available |
|
Interventions | Treatment group: acupuncture at 7 acupoints every 3 to 5 days for 20 to 30 times Control group: phenytoin 100 mg tds ± oryzanol Duration of treatment: 60 to 150 days | |
Outcomes | 75% or greater reduction in seizure frequency 50% or greater reduction in seizure frequency | |
Notes | Duration of follow‐up: 6 months | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Random sequence generation was not described |
Allocation concealment (selection bias) | Unclear risk | Allocation concealment was not described |
Blinding (performance bias and detection bias) All outcomes | High risk | The participants and personnel and outcome assessors were not blinded |
Blinding of participants and personnel (performance bias) All outcomes | High risk | The participants and personnel and outcome assessors were not blinded |
Blinding of outcome assessment (detection bias) All outcomes | High risk | The outcome assessors were not blinded |
Incomplete outcome data (attrition bias) All outcomes | Low risk | There were no dropouts |
Selective reporting (reporting bias) | Low risk | All outcomes were reported |
Other bias | High risk | The comparability of the groups at baseline was questionable since there were no data on aetiology and duration of epilepsy, current AED treatments, and frequency of seizures at baseline. There was no sham or placebo control and hence there might be placebo effect which causes bias |