Table 1.

Variation in the measurement of MM MRD related parameters between participants using their own analysis method (Stage 1).

Sample No.	#1	#2	#3*	#4	#5	#6	#7	#8*	Mean CV
Total Cells Analysed
Mean	6,707,285	6,846,778	2,186,043	6,993,562	7,167,311	7,900,975	7,379,873	4,181,342
SD	2,526,914	2,188,275	586,730	2,159,761	2,319,217	2,381,478	2,361,154	1,431,501
CV, %	37.67	31.96	26.84	30.88	32.36	30.14	31.99	34.24	32.01
Total Normal PCs
Mean	2,098	298	1,014	302	3,136	6,696	423	332
SD	1,031	118	435	148	1292	2676	1,382	165
CV, %	49.14	39.60	42.90	49.01	41.20	39.96	326.71	49.70	79.78
Total Abnormal PCs
Mean	436	664	71	133	81	5,355	8,949	79
SD	234	311	187	96	60	2,676	5,612	150
CV, %	53.67	46.84	263.38	72.18	74.07	49.97	62.71	189.87	101.59
MRD Level, %
Mean	0.0063	0.0096	0.0034	0.0019	0.0011	0.0660	0.1117	0.0019
SD	0.0026	0.0033	0.0077	0.0010	0.0007	0.0247	0.0548	0.0031
CV, %	41.27	34.38	226.47	52.63	63.64	37.42	49.06	163.16	83.5
Limit of Detection, %
Mean	0.0004	0.0004	0.0011	0.0004	0.0004	0.0003	0.0003	0.0006
SD	0.0003	0.0002	0.0005	0.0002	0.0002	0.0002	0.0001	0.0003
CV, %	75.00	50.00	45.45	50.00	50.00	66.67	33.33	50.00	52.55
Lower Limit of Quantification, %
Mean	0.0009	0.0008	0.0025	0.0008	0.0008	0.0007	0.0008	0.0014
SD	0.0005	0.0003	0.0008	0.0003	0.0003	0.0002	0.0003	0.0005
CV, %	55.56	37.50	32.00	37.50	37.50	28.57	37.50	35.71	37.73
Total Mast Cells
Mean	333	619	396	129	1,283	678	319	168
SD	1,084	2,214	1,396	228	4,536	1,729	228	311
CV, %	325.53	357.67	352.53	176.74	353.55	255.01	71.47	185.12	259.7
Total Hematogones
Mean	50,829	5,429	18,384	6,883	64,394	358,146	7,643	20,138
SD	205,308	18,641	41,067	9,859	265,795	489,049	23,486	24,586
CV, %	403.92	343.36	223.38	143.24	409.33	136.55	307.29	122.09	261.15

^*Samples considered to be MRD-negative

Bold values represent maximum, minimum, and mean CVs