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. 2023 Apr 15;214:105605. doi: 10.1016/j.antiviral.2023.105605

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© 2023 Published by Elsevier B.V.

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Fig. 3 — ¹⁸F-FDG uptake determined by tracking of the posterior nasal soft tissues using micro-PET/CT images.

A. Representative ¹⁸F-FDG micro-PET/CT images from groups of WT aged hamsters (10⁵ PFU), young hamsters (mock, 10⁵ PFU, and 10³ PFU) and adult hACE2 hamsters (100 and 1 PFU) exposed to SARS-CoV-2 intranasally with different doses (columns from left to right) in the sagittal plane show metabolic activities located in the regions of interests (nasal tissues; white arrow) for each indicated study day (rows from top to bottom). B. Quantitation of ¹⁸F-FDG uptake in nasal cavities. Normalized nasal SUVmean was calculated to reflect the longitudinal change of the ¹⁸F-FDG uptake in the nasal and nasopharyngeal structures at the different days post-exposure. Data are presented as the mean percentage of the normalized nasal SUVmean (±SD). Imaging data were analyzed using GraphPad Prism 9.3.1. Two-way ANOVA with Tukey multiple comparison test was used to determine statistical significance. ¹⁸F-FDG, 2-deoxy-2-[fluorine-18]fluoro-D-glucose; micro-PET, micro-positron emission tomography; CT, computed tomography; WT, wild-type; hACE2, human angiotensin-converting enzyme 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; SUV, standardized uptake value; SD, standard deviation; ANOVA, analysis of variance; BL, baseline; D2, day 2; D5, day 5; D8, day 8.