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. 2023 Apr 14;13:73. doi: 10.1186/s13578-023-01020-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — BCL6 attenuates malignant phenotypes in AGS and SGC-7901 cells. A Expression levels of BCL6 in AGS and SGC-7901 cells infected with BCL6 overexpression virus and empty virus were analyzed by western blotting assay (***p < 0.001). B, C BCL6 inhibits the viability and proliferation of AGS and SGC-7901 cells (***p < 0.001). D BCL6 inhibited the migration of AGS and SGC-7901 cells (***p < 0.001). E BCL6 inhibited the migration and invasion of AGS and SGC-7901 cells (***p < 0.001). F BCL6 inhibited the EMT process of AGS and SGC-7901 cells. G BCL6 inhibited the growth of SGC-7901 cells in vivo. Tumor growth curves and tumor weight shows the inhibitory effect of BCL6 on tumor in vivo (N = 6) (*p < 0.05, ***p < 0.001). H Representative hematoxylin and eosin (HE) staining and immunohistochemical (IHC) images of tumor xenografts derived from SGC-7901-NC, SGC-7901-BCL6 cell lines stained by BCL6 antibody (Original magnification, × 400). I BCL6 inhibited the intraperitoneal metastasis of SGC-7901 cells in vivo. Number and weight of disseminated tumour foci shows the metastasis inhibitory effect of BCL6 on tumor in vivo (**p < 0.01). J Representative HE and IHC staining of metastatic foci derived from SGC-7901-NC, SGC-7901-BCL6 cell lines (Original magnification, × 400)