The protein–protein interaction network analysis using STRING database. A search of the STRING database with PKCε and the 39 validated, putative PKCε substrates resulted in a network with 40 nodes and 52 edges, with a PPI enrichment value of <1.0e-16. Node color represents functional annotations from Gene Ontology resource: Blue = Synapse; Red = Cytoskeleton Organization, Yellow = Actin Binding. PKCε, PKC epsilon; PPI, protein–protein interaction.