Fig. 14.

Knockdown of CENPO inhibited tumor growth in mouse xenograft models. The mouse xenograft model was established to observe the effects of CENPO knockdown on tumor volume (A, B), weight (C), and fluorescence expression intensity (D). E Tumor tissues were separated from mice for HE and IHC staining for detecting KI67 expression in mouse tumor tissues of shCENPO group and shCtrl group. Scale bar = 100 µm. F The expression of the target proteins of mTOR pathways was observed by western blotting in NCI-H1299 cells. The protein blot images are cropped. The presented results were representative of experiments repeated at least three times. Data was represented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001