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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Psychoneuroendocrinology. 2023 Jan 2;149:106023. doi: 10.1016/j.psyneuen.2023.106023

Table 2.

Associations of social isolation with the digit symbol substitution test score (n = 2,535)

Weighted β coefficients (Standard Error)

Men (n = 1,267) Women (n = 1,268)

Model 1 Model 2 Model 3 Model 4 Model 1 Model 2 Model 3 Model 4

Variables

Social isolation (Ref. No) −8.795 (1.772)*** −3.542 (1.471)** −2.828 (1.188)** −2.445 (1.180)** −9.190 (1.492)*** −5.072 (1.213)*** −5.761 (1.166)*** −5.478 (1.167)***
Age −0.688 (0.061)*** −0.710 (0.063)*** −0.724 (0.067)*** −0.870 (0.069)*** −0.827 (0.074)*** −0.816 (0.079)***
Race/ethnicity (Ref. Non-Hispanic white)
 Non-Hispanic black −7.392 (1.679)*** −7.163 (1.620)*** −7.258 (1.669)*** −14.162 (1.649)*** −13.330 (1.607)*** −13.045 (1.648)***
 Hispanics −3.489 (1.937) −4.127 (1.920)* −3.362 (1.977) −0.160 (1.829) −0.097 (1.821) −0.222 (1.856)
 Others −11.573 (3.649)** −12.075 (3.744)** −12.230 (3.795)** −6.758 (3.796) −4.650 (3.545) −4.584 (3.594)
Educational attainment (Ref. Less than high school)
 High school graduate 8.635 (1.362)*** 7.957 (1.387)*** 8.108 (1.425)*** 9.880 (1.393)*** 9.862 (1.382)*** 9.604 (1.420)***
 More than high school 12.943 (1.263)*** 11.952 (1.271)*** 12.120 (1.305)*** 13.774 (1.397)*** 13.030 (1.362)*** 12.039 (1.414)***
Annual household income (Ref. <$20,000)
 $20,000-$75,000 6.860 (1.108)*** 6.233 (1.141)*** 5.978 (1.184)*** 4.236 (1.228)*** 4.046 (1.238)** 4.249 (1.259)***
 >$75,000 11.912 (1.533)*** 10.945 (1.515)*** 10.518 (1.568)*** 5.292 (1.757)** 4.952 (1.755)** 4.929 (1.745)**
Smoking status (Ref. Nonsmoker)
 Former smoker −2.716 (1.038)** −2.407 (1.087)* 0.413 (1.261) 0.902 (1.293)
 Current smoker −3.295 (1.590)* −3.565 (1.671)* 0.795 (1.663) 1.115 (1.703)
Alcohol intake ≥12 drinks/year (Ref. No) 2.143 (1.081)* 1.750 (1.127) 2.361 (1.185)* 1.817 (1.223)
Moderate/vigorous physical activities (Ref. No) 2.310 (1.050)* 1.981 (0.880)* 2.530 (1.096)* 2.360 (1.107)*
Obesity (Ref. No) −0.987 (1.062) −0.601 (1.185)
Hypertension (Ref. No) −1.479 (0.457)* −0.671 (0.576)
Diabetes mellitus (Ref. No) −1.818 (0.476)** −2.869 (0.654)**

Model Fit

F 24.633 81.630 43.033 56.245 37.924 79.809 43.591 57.390
Significance 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
R2 0.027 0.439 0.439 0.447 0.037 0.427 0.438 0.443

Note:

Model 1: unadjusted.

Model 2: adjusted for sociodemographic variables (age, race/ethnicity, education, and income).

Model 3: additionally adjusted for behavioral characteristics (smoking, alcohol intake, and physical exercise).

Model 4: additionally adjusted for health-related characteristics (obesity, hypertension, and diabetes).

*

p < 0.05,

**

p < 0.01,

***

p < 0.001