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. 2023 Apr 15;13:6141. doi: 10.1038/s41598-023-33363-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Similar trends between the onset trend of female and estrogen physiological rhythm in Xp11.2 tRCC. (A) Flow diagram of study selection. (B) The gender distribution in different age groups. (C) The trend of the onset time of Xp11.2 tRCC cases in female and estrogen levels. (D) Correlation analysis of the trends of female cases and estrogen changing trend with age. n.s.: p ≥ 0.05; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.