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. 2023 Apr 15;14:2157. doi: 10.1038/s41467-023-37928-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Mitochondria activities in HSCR-ENCCs treated with FAO agonist (GW9508), SAG, and SAG in combination with ETO were monitored using the Mitotracker assay. The corresponding quantitative analyses of mitochondria activities in HSCR#20- and HSCR#17-ENCCs from three independent experiments are shown in (b, c). Black lines mark the mean values ± SEM. d Immunocytochemistry of TUJ1⁺ and NF⁺ neurons on day 5 of neuronal differentiation. e Bar charts show mean values ± SEM from 3–4 independent experiments (Student’s t-test, two-sided). f Schematic shows the differentiation strategy for the generation of HSCR-ENCCs. g Immunocytochemistry of TUJ1⁺ and TH⁺ neurons on day 9 of the neuronal differentiation of control and HSCR-ENCC with or without pretreatment with SAG. h The bar charts show the mean values ± SEM from independent experiments. Data points obtained from independent experiments are shown (two-way ANOVA test). i Schematic shows that Hedgehog-mediated glycolysis and FAO regulate the survival and differentiation of ENCCs. Source data are provided as a Source Data file.