Table 1.
Demographics, microbiology and radiology data of patients with presumptive mycobacterial lung diseases
| Internal cohort, training (n = 660) | Internal cohort, internal test (n = 120) | External cohort, external test (n = 600) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TB | NTM-LD | Imitator | p | TB | NTM-LD | Imitator | p | TB | NTM-LD | Imitator | p | |
| (N = 220) | (N = 220) | (N = 220) | (n = 40) | (n = 40) | (n = 40) | (n = 200) | (n = 200) | (n = 200) | ||||
| Age (years)* | 64.3 ± 18.2 | 67.7 ± 12.7 | 66.2 ± 15.7 | 0.075 | 66.8 ± 18.7 | 70.1 ± 10.2 | 62.0 ± 16.1 | 0.063 | 55.0 ± 20.5 | 65.9 ± 15.4 | 65.8 ± 12.4 | < 0.001 |
| Male, n (%) | 143 (65%) | 104 (47%) | 101 (46%) | < 0.001 | 29 (73%) | 19 (48%) | 16 (40%) | 0.010 | 140 (70%) | 110 (55%) | 83 (42%) | < 0.001 |
| Acid-fast smear | < 0.001 | < 0.001 | < 0.001 | |||||||||
| High-grade positive (3, 4) | 53 (24%) | 34 (16%) | 0 (0%) | 8 (20%) | 9 (23%) | 0 (0%) | 73 (37%) | 17 (9%) | 0 (0%) | |||
| Low-grade positive (1, 2) | 47 (21%) | 51 (23%) | 0 (0%) | 9 (23%) | 8 (20%) | 0 (0%) | 48 (24%) | 34 (17%) | 0 (0%) | |||
| Negative | 120 (55%) | 135 (61%) | 220 (100%) | 23 (58%) | 23 (58%) | 40 (100%) | 79 (40%) | 149 (75%) | 200 (100%) | |||
| Chest X-ray pattern | ||||||||||||
| Fibrocalcific change | 100 (46%) | 80 (36%) | 68 (31%) | 0.006 | 13 (33%) | 13 (33%) | 8 (20%) | 0.358 | 71 (36%) | 67 (34%) | 69 (35%) | 0.915 |
| Nodule or mass* | 109 (50%) | 98 (45%) | 58 (26%) | < 0.001 | 29 (73%) | 16 (40%) | 13 (33%) | 0.001 | 128 (64%) | 134 (67%) | 92 (46%) | < 0.001 |
| Cavitation* | 42 (19%) | 22 (10%) | 14 (6%) | < 0.001 | 4 (10%) | 5 (13%) | 2 (5%) | 0.496 | 65 (33%) | 30 (15%) | 7 (4%) | < 0.001 |
| Consolidation | 118 (54%) | 75 (34%) | 108 (49%) | < 0.001 | 22 (55%) | 22 (55%) | 17 (43%) | 0.434 | 118 (59%) | 61 (31%) | 76 (38%) | < 0.001 |
| Bronchiectasis* | 23 (11%) | 116 (53%) | 67 (31%) | < 0.001 | 11 (28%) | 21 (53%) | 20 (50%) | 0.046 | 24 (12%) | 122 (61%) | 57 (29%) | < 0.001 |
| Pleural effusion | 18 (8%) | 3 (1%) | 15 (7%) | 0.004 | 8 (20%) | 2 (5%) | 1 (3%) | 0.014 | 21 (4%) | 0 (0%) | 7 (1%) | < 0.001 |
| Chest X-ray extent | ||||||||||||
| Multifocala | 133 (61%) | 141 (64%) | 106 (48%) | 0.002 | 28 (70%) | 26 (65%) | 17 (43%) | 0.029 | 134 (67%) | 151 (76%) | 92 (46%) | < 0.001 |
NTM-LD, nontuberculous mycobacterial lung disease; TB, tuberculosis
aFor the evaluation of the extent of lung involvement, each lung was divided into 3 areas. The pulmonary lesions with involvement in more than one lung area were regarded as multifocal
*p < 0.05 compared among training, internal test sets of the internal cohort, and the external test set of the external cohort