. 2023 Apr 16;23:72. doi: 10.1186/s12935-023-02918-6

Table 2.

Genotypes distribution of NRF2 rs6721961 and rs6726395 in four groups and the risks of CHB, LC, and HCC patients

Genotypes	Controls (N = 217)	CHB (N = 110)	LC (N = 86)	HCC (N = 260)	CHB vs. controls		LC vs. controls		HCC vs. controls		HCC vs. CHB
Genotypes	Controls (N = 217)	CHB (N = 110)	LC (N = 86)	HCC (N = 260)	OR (95% CI)^a	P	OR (95% CI) ^a	P	OR (95% CI)^a	P	OR (95% CI)^a	P
rs6721961
G allele	333	178	137	387	1.00^ref		1.00^ref		1.00^ref		1.00^ref
T allele	101	42	35	133	0.752 (0.477–1.186)	0.220	0.830 (0.525–1.314)	0.427	1.192 (0.858–1.657)	0.295	1.561 (1.003–2.430)	0.048
GG	128	75	52	143	1.00^ref		1.00^ref		1.00^ref		1.00^ref
GT	77	28	33	101	0.701 (0.390–1.260)	0.235	1.073 (0.613–1.876)	0.806	1.402 (0.913–2.153)	0.123	2.298 (1.282–4.119)	0.005
TT	12	7	1	16	0.685 (0.222–2.114)	0.511	0.185 (0.023–1.518)	0.116	1.042 (0.447–2.428)	0.925	1.129 (0.390–3.267)	0.823
TT + GT vs.GG^b					0.670 (0.366–1.227)	0.195	0.894 (0.484–1.648)	0.719	1.443 (0.908–2.292)	0.121	2.039 (1.184–0.510)	0.010
TT vs. GG + GT^c					0.899 (0.286–2.824)	0.856	0.224 (0.028–1.829)	0.163	0.953 (0.408–2.224)	0.911	0.707 (0.237–2.109)	0.534
rs6726395
G allele	258	139	111	324	1.00^ref		1.00^ref		1.00^ref		1.00^ref
A allele	176	81	61	196	0.817 (0.557–1.197)	0.299	0.839 (0.570–1.234)	0.371	0.966 (0.725–1.289)	0.816	1.033(0.707–1.508)	0.868
GG	81	41	32	103	1.00^ref		1.00^ref		1.00^ref		1.00^ref
AG	96	57	47	118	1.098 (0.615–1.959)	0.751	1.315 (0.745–2.321)	0.344	1.065 (0.690–1.646)	0.776	0.768(0.441–1.336)	0.350
AA	40	12	7	39	0.542 (0.230–1.277)	0.161	0.473 (0.185–1.211)	0.119	0.891 (0.494–1.606)	0.701	1.395(0.577–3.369)	0.460
AA + AG vs. GG^b					1.107 (0.604–2.029)	0.743	1.128 (0.612–2.076)	0.700	0.858 (0.540–1.362)	0.515	0.859 (0.504 − 0.464)	0.577
AA vs. AG + GG^c					0.519 (0.235–1.148)	0.105	0.448 (0.185–1.086)	0.075	0.867 (0.499–1.506)	0.611	1.726 (0.742–4.019)	0.205

CHB, chronic hepatitis B; LC, liver cirrhosis; HCC, hepatocellular carcinoma

^a Adjusted for gender, age, BMI, ethnicity, smoking and alcohol status

^bDominant model

^cRecessive model

Boldfaced values indicate a significant difference