TABLE 3. NMP parameters according to the result of the viability assessment and outcome after transplant.
| Discarded | Transplanted | p valuea | Functioning | PNF | p valueb | p valuec | |
|---|---|---|---|---|---|---|---|
| n | 4 | 10 | 8 | 2 | |||
| Second‐hour NMP parameters | |||||||
| Lactate, mmol/L | 11.1 (9.1, 13.7) | 1.4 (1.1, 2.2) | <0.01 | 1.3 (1.0, 1.5) | 3.2 (2.8, 3.6) | 0.07 | 0.01 |
| pH | 7.2 (7.1, 7.2) | 7.3 (7.3, 7.4) | 0.07 | 7.3 (7.3, 7.4) | 7.3 (7.3, 7.3) | 0.60 | 0.06 |
| Potassium, mmol/L | 19.0 (15.3, 19.2) | 5.4 (3.6, 7.8) | 0.07 | 5.1 (3.2, 6.9) | 7.4 (6.2, 8.5) | 0.30 | 0.06 |
| Glucose, mg/dl | 561 (407, 635) | 380 (225, 482) | 0.26 | 380 (325, 427) | 334 (245, 422) | 1.00 | 0.23 |
| HA flow, ml/min/kg | 101 (91, 122) | 217 (168, 234) | 0.01 | 224 (204, 257) | 140 (129, 152) | 0.04 | 0.01 |
| PV flow, ml/min/kg | 358 (319, 409) | 500 (468, 567) | 0.01 | 514 (496, 640) | 431 (423, 440) | 0.04 | 0.01 |
| Bile production, ml | 2.5 (0.0, 6.2) | 8.0 (5.0, 27.5) | 0.07 | 8.0 (5.0, 22.5) | 47.5 (26.2, 68.8) | 0.69 | 0.08 |
| AST, IU/L | 20,225 (14,615, 22,960) | 4931 (3817, 6756) | 0.04 | 3823 (3053, 4383) | 8222 (7611, 8833) | 0.06 | 0.03 |
| ALT, IU/L | 18,510 (13,045, 20,270) | 4099 (3071, 5271) | 0.02 | 3113 (2496, 4064) | 5181 (5090, 5271) | 0.35 | 0.03 |
| Fourth‐hour NMP parameters | |||||||
| Lactate, mmol/L | 9.7 (8.6, 10.8) | 1.4 (1.1, 2.7) | 0.03 | 1.3 (1.1, 1.6) | 4.6 (3.8, 5.5) | 0.07 | 0.04 |
| pH | 7.2 (7.2, 7.3) | 7.4 (7.3, 7.4) | 0.13 | 7.3 (7.3, 7.4) | 7.4 (7.4, 7.4) | 0.90 | 0.19 |
| Potassium, mmol/L | 18.7 (18.5, 18.9) | 4.3 (3.2, 7.8) | 0.03 | 3.6 (2.9, 6.4) | 6.7 (5.8, 7.6) | 0.43 | 0.04 |
| Glucose, mg/dl | 519 (480, 557) | 311 (191, 352) | 0.09 | 311 (230, 341) | 308 (195, 422) | 1.00 | 0.07 |
| HA flow, ml/min/kg | 159 (151, 222) | 173 (161, 221) | 0.84 | 198 (171, 230) | 140 (129, 152) | 0.10 | 0.61 |
| PV flow, ml/min/kg | 396 (341, 422) | 548 (501, 633) | 0.02 | 548 (514, 712) | 520 (485, 556) | 0.50 | 0.02 |
| Bile production, ml | 2.5 (0.0, 13.8) | 80 (15.2, 115.0) | 0.02 | 80 (14.5, 105.0) | 75.5 (45.2, 105.8) | 0.79 | 0.03 |
| AST, IU/L | 20,225 (14,615, 22,960) | 5738 (4286, 7287) | 0.04 | 4350 (3362, 5203) | 8512 (7756, 9268) | 0.16 | 0.03 |
| ALT, IU/L | 18,510 (13,045, 20,270) | 4232 (3335, 5324) | 0.02 | 3378 (2725, 4435) | 5216 (5108, 5325) | 0.35 | 0.03 |
| Other NMP parameters | |||||||
| NaHCO3 added, mEq | 75.0 (58.8, 87.5) | 12.5 (2.5, 37.5) | 0.02 | 12.5 (7.5, 32.5) | 20.0 (10.0, 30.0) | 0.89 | 0.03 |
| Cumulative bile production, ml | 2.5 (0.0, 18.8) | 95 (41.2, 187.5) | 0.02 | 95 (43.8, 167.5) | 115 (72.5, 157.5) | 0.79 | 0.03 |
Note: Data are presented as counts (percentage) or median (IQR).
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; HA, hepatic artery; IQR, interquartile range; NMP, normothermic machine perfusion; PNF, primary nonfunction; PV, portal vein.
a
p values refer to Mann–Whitney U test results comparing discarded versus transplanted livers.
b
p values refer to Mann–Whitney U test results comparing functioning versus PNF livers.
c
p values refer to Mann–Whitney U test results comparing discarded versus functioning livers.