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. 2021 Sep 23;53(5):1759–1769. doi: 10.1017/S0033291721003378

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© The Author(s) 2021

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re- use, distribution and reproduction, provided the original article is properly cited.

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Fig. 1. — Results of mediation analysis. Independent variable = polygenic risk score for schizophrenia (PRS-Sz), dependent variable = log Total of CAPE-42 (CAPE), Mediator = cannabis use. Although the effects of each path (a, b and c) are significant, the indirect path of PRS-Sz on PLEs as measured by the CAPE-42 questionnaire through cannabis use was not significant (p > 0.05). The total effect was significant. The estimate is shown between arrows, with * signifying statistical significance. *p < 0.05, **p < 0.01.