Table 4.

Synergistic effects of childhood exposures and PRS-SZ₇₅ on case status

	PRS-SZ75 = 0		PRS-SZ75 = 1
	N cases/controls	OR (95% CI)	N cases/controls	OR (95% CI)	ICR (95% CI)
All trauma = 0	137/416	1.0	77/130	1.83 (1.26–2.65) p < 0.001	1.28 (−1.29 to 3.85)
All trauma = 1	100/104	3.38 (2.34–4.88) p < 0.001	71/43	5.33 (3.35–8.49) p < 0.001

PRS-SZ₇₅, polygenic risk score for schizophrenia (75% cut-point); ICR, interaction contrast ratio.

Data adjusted for site, sex, age and 10 PCs. Childhood adversity was measured by the CTQ dichotomised into at least one type of trauma reaching moderate to severe levels (Bernstein et al., 1994). ‘All trauma 0’ = no subtype of trauma reaching moderate to severe levels. ‘All trauma 1’ = at least one type of trauma reaching moderate to severe levels.