Table 5.
Synergistic effects of childhood exposure subtypes and PRS-SZ75 on case status
| PRS-SZ75 = 0 | PRS-SZ75 = 1 | ||||
|---|---|---|---|---|---|
| N cases/controls | OR (95% CI) | N cases/controls | OR (95% CI) | ICR (95% CI) | |
| Emotional abuse = 0 | 194/487 | 1.0 | 122/161 | 1.92 (1.39–2.65) p < 0.001 |
0.58 (−4.29 to 5.46) |
| Emotional abuse = 1 | 43/33 | 4.34 (2.54–7.42) p < 0.001 |
26/12 | 5.89 (2.74–12.46) p < 0.001 |
|
| Physical abuse = 0 | 213/503 | 1.0 | 130/168 | 1.82 (1.33–2.48) p < 0.001 |
6.25 (−6.25 to 20.88) |
| Physical abuse = 1 | 24/17 | 4.34 (2.12–8.99) p < 0.001 |
218/5 | 12.08 (4.11–35.48) p < 0.001 |
|
| Sexual abuse = 0 | 204/492 | 1.0 | 139/1665 | 2.11 (1.55–2.89) p < 0.001 |
<0.1 (−6.20 to 0.15) |
| Sexual abuse = 1 | 33/28 | 3.91 (2.21–6.93) p < 0.001 |
9/8 | 2.00 (0.66–6.04) p < 0.001 |
|
| Emotional neglect = 0 | 184/467 | 1.0 | 108/149 | 1.81 (1.29–2.53) p < 0.001 |
1.21 (−1.79 to 4.20) |
| Emotional neglect = 1 | 53/53 | 2.85 (1.80–4.51) p < 0.001 |
40/24 | 4.86 (2.69–8.78) p < 0.001 |
|
| Physical neglect = 0 | 192/483 | 1.0 | 106/157 | 1.69 (1.21–2.35) p < 0.001 |
3.68 (−1.69 to 9.06) |
| Physical neglect = 1 | 45/37 | 3.71 (2.20–6.24) p < 0.001 |
42/16 | 8.08 (4.19–15.58) p < 0.001 |
|
PRS-SZ75, polygenic risk score for schizophrenia (75% cut-point); ICR, interaction contrast ratio.
Data adjusted for site, sex, age and 10 PCs. Childhood adversity was measured by the CTQ dichotomised into at least one type of trauma reaching moderate to severe levels (Bernstein et al., 1994).