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. Author manuscript; available in PMC: 2023 Oct 14.
Published in final edited form as: Clin Cancer Res. 2023 Apr 14;29(8):1390–1402. doi: 10.1158/1078-0432.CCR-22-1491

Table 1.

List of advantages and disadvantages for T and NK cell therapies.

Cell Type Advantages Disadvantages
T Cells
  • Robust ex vivo expansion

  • Robust cytotoxicity

  • Proven efficacy in hematological malignancies

  • Possibility for long-term memory

  • Allogeneic implementation remains a challenge

NK Cells
  • Innate ability to recognize transformed cells

  • Can be generated from scalable allogeneic sources

  • Potential to achieve efficacy without triggering CRS

  • Short lifespan

  • Limited proliferative potential