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. Author manuscript; available in PMC: 2024 Apr 13.
Published in final edited form as: Cell. 2023 Feb 28;186(8):1670–1688. doi: 10.1016/j.cell.2023.01.038

Figure 3. Biosynthetic networks.

Figure 3.

Once inside the cell, nutrients—most notably glucose and glutamine—are funneled into metabolic networks that provide the building blocks necessary to produce the major macromolecules for growth: lipids, nucleotides and protein. Critical metabolic building blocks are shown in green. Major routes for ATP and reducing equivalent (NADPH) production are highlighted. Metabolic regulators commonly activated in cancer are shown in pink. Dashed lines represent transcriptional control of metabolic pathways by indicated transcription factors. PPP, pentose phosphate pathway. OXPHOS, oxidative phosphorylation.