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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Brain Behav Immun. 2023 Mar 10;110:222–236. doi: 10.1016/j.bbi.2023.03.003

Figure 4.

Figure 4.

Differential effects of repetitive blast on acute gut microbiome changes in female vs. male mice. (A). No difference in Shannon (alpha) diversity as a function of exposure type or sex. (B) PCoA on Bray-Curtis dissimilarity distances (beta diversity) among the four groups examined. Each point represents an individual sample colored according to group. Principle Component 1 (PC1): 44.6% explained variance; Principle Component 1 (PC2): 19.3% explained variance. Ellipses represent 95% CI around cluster centroid for each experimental group. (C) Differences between female sham vs. blast mice (top row) and male sham vs. blast mice (bottom row) at the order level, expressed as mean relative abundance z score (z score computed separately for female and male mice). n=18–25. Kruskal-Wallis test followed by Mann-Whitney U test for individual group by group comparison if Kruskal-Wallis was significant at FDR p<0.1 (A, C). Analysis of similarities (ANOSIM) (B). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001, ns = not significant. Values represent mean ± SEM.