Table 2.
Associations of anthropometric, metabolic, and lifestyle factors with endometrial cancer
| Cases | Controls | OR1 | 95% CI | OR2 | 95% CI | |
|---|---|---|---|---|---|---|
| BMI, kg/m2 | ||||||
| <25 | 126 | 852 | 1.00 | Reference | ||
| 25–29 | 219 | 1061 | 1.31 | 1.02, 1.67 | ||
| 30–34 | 191 | 617 | 1.94 | 1.50, 2.51 | ||
| 35–39 | 111 | 295 | 2.35 | 1.74, 3.17 | ||
| ≥40 | 144 | 225 | 3.92 | 2.91, 5.27 | ||
| Missing3 | 20 | 74 | ||||
| Ptrend | <0.0001 | |||||
| Early adulthood BMI, kg/m2 3 4 | ||||||
| <18.5 | 85 | 452 | 0.81 | 0.62, 1.06 | ||
| 18.5–24 | 405 | 1562 | 1.00 | Reference | ||
| 25–29 | 80 | 204 | 1.00 | 0.73, 1.35 | ||
| ≥30 | 45 | 84 | 1.18 | 0.78, 1.79 | ||
| Missing3 | 129 | 425 | ||||
| Ptrend | 0.19 | |||||
| Cross-classified early adulthood BMI × recent BMI, kg/m2 3 4, 5 | ||||||
| <25, <25 | 77 | 517 | 1.00 | Reference | ||
| <25, ≥25 | 412 | 1485 | 1.86 | 1.42, 2.44 | ||
| ≥25, <25 | 4 | 21 | 1.33 | 0.44, 4.06 | ||
| ≥25, ≥256 | 120 | 261 | 2.81 | 2.01, 3.92 | ||
| Missing3 | 2 | 18 | ||||
| Waist circumference, cm7 | ||||||
| <73.7 | 30 | 201 | 1.00 | Reference | ||
| 73.7–82.3 | 52 | 268 | 1.13 | 0.68, 1.86 | ||
| 82.4–89.4 | 50 | 174 | 1.30 | 0.78, 2.19 | ||
| 89.5–96.5 | 65 | 175 | 1.51 | 0.91, 2.52 | ||
| >96.5 | 85 | 165 | 1.33 | 0.79, 2.22 | ||
| Missing3 | 143 | 570 | ||||
| Ptrend | 0.25 | |||||
| Cross-classified obesity with abdominal obesity7 | ||||||
| BMI<30 kg/m2, WC≤88 cm | 83 | 469 | 1.00 | Reference | ||
| BMI≥30 kg/m2, WC≤88 cm | 37 | 120 | 1.89 | 1.20, 2.96 | ||
| BMI<30 kg/m2, WC>88 cm | 29 | 119 | 1.21 | 0.74, 1.99 | ||
| BMI≥30 kg/m2, WC>88 cm8 | 130 | 259 | 2.50 | 1.80, 3.49 | ||
| Missing3 | ||||||
| Diabetes9 | ||||||
| No | 587 | 2302 | 1.00 | Reference | ||
| Yes | 156 | 422 | 1.19 | 0.95, 1.49 | ||
| Missing3 | 1 | 3 |
BMI=body mass index, WC=waist circumference.
Adjusted for age, study, menopausal status, ever use of menopausal hormones, age at menarche, parity, ever use of oral contraceptives, and smoking status.
Adjusted for age, study, menopausal status, body mass index, ever use of menopausal hormones, age at menarche, parity, ever use of oral contraceptives, and smoking status.
Number missing within studies included in the analysis
Analysis of participants from AARP, BWHS, CCS, EDGE, FHCRC, MEC, and NYUWHS studies
Correlation coefficient between BMI at age 18–20 and adult BMI=0.47
pinteraction=0.78
Analysis of participants from AARP, BWHS, and EDGE studies
pinteraction=0.73
Analysis of participants from AARP, BWHS, CCS, EDGE, FHCRC, MEC, and NYUWHS studies