Table 1.

Basal sIPSC properties in prelimbic cortex layer 2/3 pyramidal neurons

	Treatment	Frequency (Hz)	Amplitude (pA)	Rise Time (ms)	Decay Time (ms)
sIPSCs	Naïve (n=79 cells from 50 mice)	1.99±0.12	54.1±1.3	2.07±0.04#	5.11±0.12
	Non-dependent (n=42 cells from 34 mice)	1.77±0.14	52.0±1.7	2.14±0.04##	5.39±0.19
	Dependent (n=79 cells from 47 mice)	1.99±0.13	51.9±1.3	2.09±0.04#	5.30±0.27
	Withdrawn (n=12 cells from 6 mice)	1.69±0.21	47.1±2.7	1.78±0.05	5.83±0.27

Baseline sIPSC frequencies, amplitudes, rise times and decay times in prelimbic layer 2/3 pyramidal neurons of naïve, non-dependent, dependent and 3–5 days withdrawn mice. There were significant differences in the sIPSC rise times across animal groups as compared by one-way ANOVA [rise time: F(3,214)=3.0698, p<.001], but not the other sIPSC properties [frequency: F(2,214)=0.69, p=.56; amplitude: F(3,214)=1.46, p=.22; decay time: F(3,214)=1.33, p=.26]. All data are presented as mean±SEM.

^#p<.05

^##p<.01 vs. withdrawn by Tukey’s post hoc test.