Table 3.

PLK1 Inhibitors Show Pf NEK3 Inhibition In Vitro^a

compound	% activity remaining at 2.5 μM in plasmodial kinases
	ARK1	ARK3	CDPK2	CDPK5	GSK3	NEK1	NEK3	PK5	PK6	PK9	PKB
1	100.0	100.0	80.6	100.0	99.4	94.5	4.7 (86 ± 11)	100.0	94.6	97.2	100.0
2	53.4	73.5	100.0	100.0	100.0	93.3	39.6 (1480 ± 150)	100.0	94.8	100.0	64.2
11	100.0	83.6	100.0	100.0	100.0	93.8	11.1 (130 ± 20)	100.0	67.3	100.0	49.3
12	99.5	96.2	100.0	100.0	100.0	100.0	9.7 (19 ± 30)	100.0	100.0	100.0	100.0
18	73.9	84.6	24.0 (390 ± 50)	88.1	100.0	96.4	15.4 (630 ± 120)	100.0	78.9	78.7	12.3 (250 ± 60)
19	77.9	83.6	36.1 (780 ± 90)	100.0	100.0	90.1	18.5 (1820 ± 210)	100.0	91.0	85.7	14.8 (790 ± 140)

^aValues are % activity remaining.

Values in parentheses are IC₅₀ values in nM ± SD.