Table 3.
Lead variants and candidate genes for genome-wide significant loci of each left ventricle (LV) trait.
| LV trait | RSID | Chr | hg19 position |
Ref | Alt | Beta | P | Candidate gene |
|---|---|---|---|---|---|---|---|---|
| Sphericity index | rs11756438 | 6 | 118993632 | C | A | 0.004 | 1.16x10−15 | PLN |
| Sphericity index | rs1461990 | 8 | 108087628 | C | G | 0.003 | 4.90x10−10 | ANGPT1 |
| Sphericity index | none | 3 | 73578036 | AACACAC | A | 0.003 | 2.28x10−8 | PDZRN3 |
| Sphericity index | rs199682224 | 6 | 32486364 | G | T | 0.006 | 3.58x10−8 | HLA-DRB5 |
| Short axis length | rs57912492 | 6 | 118702621 | C | T | 0.24 | 2.43x10−10 | PLN |
| Short axis length | rs462797 | 16 | 22832777 | G | A | 0.46 | 2.93x10−8 | HS3ST2 |
| Short axis length | rs111692972 | 2 | 179669931 | C | T | −0.44 | 4.48x10−8 | TTN |
| Long axis length | none | 3 | 73578036 | AACACAC | A | −0.37 | 4.31x10−9 | PDZRN3 |
| Long axis length | rs72007904 | 8 | 108085680 | A | AACTATTC | −0.36 | 7.33x10−9 | ANGPT1 |